| Date/Season | Transaction |
|---|
| 4/21/2024 | Philadelphia Flyers send Mattias Janmark, Dylan DeMelo to the St Louis Blues for Brayden Tracey, BOS 2033 Rnd 3 |
| 9/13/2020 | Philadelphia Flyers send Reilly Smith, Gabriel Bourque, WPG 2028 Rnd 3 to the Buffalo Sabres for Dylan DeMelo |
| 9/7/2020 | Winnipeg Jets send Jaccob Slavin, Dylan DeMelo, Neil Pionk to the Buffalo Sabres for John Gilmour, Jared Tinordi |
| 5/11/2020 | New Jersey Devils send Dylan DeMelo to the Winnipeg Jets for Oliver Kylington, $600,000 |
| 10/12/2018 | Buffalo Sabres send Dylan DeMelo, $500,000 to the New Jersey Devils for Kristers Gudlevskis, Ryan Getzlaf (rental), OTT 2023 Rnd 3, VAN 2023 Rnd 3 |
| 2022 | Drafted in the 2nd round, 45th overall by Buffalo |
