| Date/Season | Transaction |
|---|
| 12/3/2023 | Dallas Stars send Guillaume Richard, DAL 2032 Rnd 3, $250,000 to the Colorado Avalanche for Simon Despres (rental) |
| 4/13/2022 | Colorado Avalanche send Donovan Sebrango, CAR 2028 Rnd 1 to the Calgary Flames for Simon Despres |
| 1/16/2021 | San Jose Sharks send Simon Despres, SJS 2027 Rnd 1, SJS 2028 Rnd 1 to the Calgary Flames for Drew Doughty (rental) |
| 8/6/2016 | San Jose Sharks send Alexander Vasyunov, Jay McClement, Matthew Nieto, PIT 2026 Rnd 1 to the Pittsburgh Penguins for Lauri Tukonen, Simon Despres, Stefan Legein |
| 6/17/2016 | Pittsburgh Penguins send Vladimir Mihalik to the Calgary Flames for John DeGray, Simon Despres |
| 6/6/2016 | Winnipeg Jets send Simon Despres to the Calgary Flames for PIT 2021 Rnd 2, $500,000 |
| 5/17/2016 | Winnipeg Jets send John Erskine to the Montreal Canadiens for Simon Despres, $1,865,714 |
| 1/26/2012 | Montreal Canadiens send 8th overall pick in Inclusion Draft to the Anaheim Ducks for Shaone Morrisonn, Simon Despres, Viktor Stalberg |
| 9/5/2011 | Philadelphia Flyers send Jean-François Soucy, Simon Despres to the Anaheim Ducks for Ludvig Rensfeldt, Mattias Weinhandl, Mike Egener |
| 8/17/2011 | Colorado Avalanche send Jason King, Matt Clark, Simon Despres to the Philadelphia Flyers for Mike Komisarek, Tomas Fleischmann |
| 5/2/2010 | Ottawa Senators send Fabian Brunnstrom, Mattias Tedenby, Simon Despres, ANA 2013 Rnd 2 to the Colorado Avalanche for Alexander Frolov, Ladislav Smid |
| 1/20/2010 | Ottawa Senators send Patrik Stefan to the Pittsburgh Penguins for Simon Despres, PIT 2014 1st |
| 2013 | Drafted in the 2nd round, 32nd overall by Pittsburgh (from Anaheim) |
